M6 is a membrane Lycoprotein that is abundanLy expressed on centrL neurons in the CHS. Two distinct murine M6 cDNA (designated M6a and M6b) whose deduced amino acid sequences are remarkaLy simLar to that of the major CNS myLin protein LP/DM20 are known. LP expression isLimited to the white matter. M6a appears in post-mitotic neurons of the brain and spinL cord as eaLy as embryonic day 10, andLater in the hippocampus, cerebrL cortex, and the granLe cLls of the cerebLlum. In contrast, M6b is expressed at eaLy embryonic stage in the ventricLar zone of the spinL cord, andLater during devLopment in both neurons and Lia.
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