The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Pathway
Alanine; Amino acid synthesis and interconversion (transamination); Arginine and proline metabolism; D-Glutamine and D-glutamate metabolism; GABAergic synapse; Glutamate Neurotransmitter Release Cycle; Glutamatergic synapse; Metabolism
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