Anti-GLRX monoclonal antibody, clone 4D22

Antibody Isotype

IgG2a

Clone

4D22

Species Reactivity

Human

Immunogen

GLRX (AAH10965, 1 a.a. ~ 106 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

GLRX; glutaredoxin (thioltransferase); glutaredoxin-1; GRX; GRX1; TTase-1; thioltransferase-1; FLJ43648; MGC117407;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.

Pathway

Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Synthesis and interconversion of nucleotide di- and triphosphates, organism-specific biosystem; ascorbate recycling (cytosolic), organism-specific biosystem;