Anti-GLB1 (aa 80-109) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Human GLB1 aa 80-109 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: P16278

Conjugate

Application Notes

WB: 1/100 - 1/500.

Alternative Names

GLB1; galactosidase, beta 1; elastin receptor 1 (67kD); elastin receptor 1, 67kDa; ELNR1; beta-galactosidase; EBP; lactase; acid beta-galactosidase; elastin receptor 1, 67kDa; ELNR1; MPS4B;

Entrez Gene ID

UniProt ID

Antigen Description

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.

Pathway

Galactose metabolism; Glycosaminoglycan degradation; Glycosphingolipid biosynthesis - ganglio series; Glycosphingolipid metabolism;