The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Pathway
Fatty Acid Beta Oxidation; Fatty acid, triacylglycerol, and ketone body metabolism; Glycerolipid metabolism; Metabolism; Metabolism of lipids and lipoproteins; PPAR signaling pathway; Triacylglyceride Synthesis; Triglyceride Biosynthesis; Type II diabetes mellitus; glycerol degradation I.
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