Anti-GJA8 (aa 301-410) polyclonal antibody

Species Reactivity

Human

Immunogen

GJA8 (NP_005258, 301 a.a. ~ 410 a.a) partial recombinant protein with GST tag. The sequence is EEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEE QEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTT

Conjugate

Alternative Names

GJA8; gap junction protein, alpha 8, 50kDa; CAE; CAE1; CX50; CZP1; MP70; CTRCT1; gap junction alpha-8 protein; connexin 50; connexin-50; lens fiber protein MP70; cell surface glycoprotein; gap junction protein alpha 8 50kDa; lens intrinsic membrane protei

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.

Pathway

Calcium Regulation in the Cardiac Cell; Gap junction trafficking; Membrane Trafficking;