Anti-SLX1B monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human GIYD2 is used for rabbit immunization.

Conjugate

Alternative Names

SLX1B; SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae); GIYD2; structure-specific endonuclease subunit SLX1; GIY-YIG domain-containing protein 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene.

Pathway

Fanconi anemia pathway;