GGPS1 (NP_004828, 201 a.a. ~ 300 a.a) partial recombinant protein with GST tag. The sequence is NKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYT RNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene.
Pathway
Activation of gene expression by SREBF (SREBP); Metabolism; Regulation of cholesterol biosynthesis by SREBP (SREBF); Terpenoid backbone biosynthesis
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