Anti-GCNT2 (aa 181-293) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

antigen sequence, corresponding to amino acids 181-293 of Human GCNT2 Isoforms A and C (Q8N0V5, Q8NFS9).

Conjugate

Application Notes

IHC-P: 1/200 - 1/500; WB: 1/250 - 1/500.

Alternative Names

GCNT2; glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); cataract, congenital; CCAT, GCNT5, glucosaminyl (N acetyl) transferase 2, I branching enzyme; glucosaminyl (N acetyl) transferase 2, I branching enzyme (Ii blood group); glu

Entrez Gene ID

UniProt ID

Antigen Description

GCNT2 is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase that converts linear into branched poly-N-acetyllactosaminoglycans and is responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding 3 different isoforms have been described.

Pathway

Glycosphingolipid biosynthesis - lacto and neolacto series; Metabolic pathways;