Anti-GAR1 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human GAR1 is used for rabbit immunization.

Conjugate

Alternative Names

GAR1; GAR1 ribonucleoprotein; NOLA1; H/ACA ribonucleoprotein complex subunit 1; snoRNP protein GAR1; GAR1 ribonucleoprotein homolog; nucleolar protein family A member 1; nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs);

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.

Pathway

H/ACA ribonucleoprotein complex; Ribosome biogenesis in eukaryotes;