GALNT7 (NP_059119, 559 a.a. ~ 657 a.a) partial recombinant protein with GST tag. The sequence is LGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFT HIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV
This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation.
Pathway
Metabolism of proteins; Mucin type O-Glycan biosynthesis; O-glycan biosynthesis, mucin type core; O-linked glycosylation of mucins
Citations
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