Anti-FOXA3 (C-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to Human FOXA3 aa 250 to the C-terminus conjugated to Keyhole Limpet Haemocyanin (KLH).Database link: P55318

Conjugate

Application Notes

WB: 1 μg/ml.

Alternative Names

FOXA3; forkhead box A3; hepatocyte nuclear factor 3, gamma; HNF3G; hepatocyte nuclear factor 3-gamma; HNF-3G; TCF-3G; HNF-3-gamma; forkhead box protein A3; transcription factor 3G; fork head-related protein FKH H3; hepatocyte nuclear factor 3, gamma; FKHH

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor that is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.

Pathway

Developmental Biology; FOXA transcription factor networks; FOXA1 transcription factor network; FOXA2 and FOXA3 transcription factor networks; Maturity onset diabetes of the young; Regulation of beta-cell development;