Mouse anti-Human FOSL1 monoclonal antibody for WB, IHC-P
FOSL1 (FOS Like Antigen 1) is a Protein Coding gene. Diseases associated with FOSL1 include pfeiffer syndrome. Among its related pathways are Wnt Signaling Pathway (WikiPathways) and Corticotropin-releasing hormone. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOSL2. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene.
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Protein Symbol:P15407-FOSL1_HUMANRecommended name:Fos-related antigen 1Protein Accession:P15407Secondary Accessions:B4DR11Q6FG51Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene. The function about FOSL1 antigen include protein binding; protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity.
Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Osteoclast differentiation, organism-specific biosystem.
Lesniewski, ML; Fanning, LR; et al. Transcription factor BACH2 inhibits AP1 proteins JUNB and FosL1 in umbilical cord blood (UCB) CD4+T-cells.. BLOOD 108:494A-495A(2006).
Laritano, D; Carinci, F; et al. P15 (R) INDUCES RUNX2 IN BONE MARROW DERIVED STEM CELLS. EUROPEAN JOURNAL OF INFLAMMATION 10:95-100(2012).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.