Anti-FOSL1 monoclonal antibody (DCABH-586)

Mouse anti-Human FOSL1 monoclonal antibody for WB, IHC-P Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
23G0
Species Reactivity
Human
Immunogen
Protein expressed in 293T cell transfected with Human FRA1 expression vector.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; IHC-P: 1/50;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
FOSL1; FOS-like antigen 1; fos-related antigen 1; fra 1; FOS-like antigen-1; FRA
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FOSL1 (FOS Like Antigen 1) is a Protein Coding gene. Diseases associated with FOSL1 include pfeiffer syndrome. Among its related pathways are Wnt Signaling Pathway (WikiPathways) and Corticotropin-releasing hormone. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOSL2. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene.
Antigen Description
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Protein Symbol:P15407-FOSL1_HUMANRecommended name:Fos-related antigen 1Protein Accession:P15407Secondary Accessions:B4DR11Q6FG51Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene. The function about FOSL1 antigen include protein binding; protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity.
Pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Osteoclast differentiation, organism-specific biosystem.

Citations


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References


Perrotti, V; Palmieri, A; et al. Effect of titanium surface topographies on human bone marrow stem cells differentiation in vitro. ODONTOLOGY 101:133-139(2013).
Jiang, ZL; Guerrero-Netro, HM; et al. Divergence of intracellular signaling pathways and early response genes of two closely related fibroblast growth factors, FGF8 and FGF18, in bovine ovarian granulosa cells. MOLECULAR AND CELLULAR ENDOCRINOLOGY 375:97-105(2013).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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