Anti-FMO5 monoclonal antibody (DCABH-11588) Made to order

Rabbit anti-Human FMO5 monoclonal antibody for ICC/IF, IHC-P, IP, WB

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Human
Immunogen
A synthetic peptide of human FMO5 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FMO5; flavin containing monooxygenase 5; dimethylaniline monooxygenase [N-oxide-forming] 5; FMO 5; dimethylaniline oxidase 5; hepatic flavin-containing monooxygenase 5
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FMO5 (Flavin Containing Monooxygenase 5) is a Protein Coding gene. Diseases associated with FMO5 include trimethylaminuria and atrioventricular septal defect. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Phase II conjugation. GO annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is FMO2. Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.
Antigen Description
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. Dimethylaniline monooxygenase [N-oxide-forming] 5 is an enzyme that in humans is encoded by the FMO5 gene. 0The function about FMO5 antigen include N,N-dimethylaniline monooxygenase activity; N,N-dimethylaniline monooxygenase activity; NADP binding; flavin adenine dinucleotide binding; monooxygenase activity.
Pathway
Drug metabolism - cytochrome P45, organism-specific biosystem; Drug metabolism - cytochrome P45, conserved biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Gelb, BD; Zhang, J; et al. Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor A genes on 1q21. GENOMICS 39:409-411(1997).
Overby, LH; Carver, GC; et al. Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans. CHEMICO-BIOLOGICAL INTERACTIONS 106:29-45(1997).

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