Anti-FKBP5 monoclonal antibody (DCABH-665)

Mouse anti-Human FKBP5 monoclonal antibody for WB, IHC-P, FC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
4F0
Species Reactivity
Human
Immunogen
293T cells transfected with Human FKBP51 expression vector.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; IHC-P: 1/50; Flow Cyt: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
FKBP5; FK506 binding protein 5; peptidyl-prolyl cis-trans isomerase FKBP5; FKBP51; FKBP54; P54
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FKBP5 (FK506 Binding Protein 5) is a Protein Coding gene. Diseases associated with FKBP5 include major depressive disorder and accelerated response to antidepressant drug treatment and glucocorticoid resistance. Among its related pathways are Prostate Cancer and TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is FKBP1A. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
Antigen Description
Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature corticoid receptor hetero-complexes (i. e. progesterone-, glucocorticoid-, mineralocorticoid-receptor complexes) along with the 90 kDa heat shock protein and P23 protein. The function about FKBP5 antigen include FK506 binding; binding; heat shock protein binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity.
Pathway
Glucocorticoid receptor regulatory network, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem.

Citations


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References


Attwood, BK; Bourgognon, JM; et al. Neuropsin cleaves EphB2 in the amygdala to control anxiety. NATURE 473:372-U553(2011).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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