Anti-FIG4 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide of human FIG4 is used for rabbit immunization.

Conjugate

Alternative Names

FIG4; FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae); YVS; SAC3; ALS11; CMT4J; KIAA0274; dJ249I4.1; polyphosphoinositide phosphatase; SAC domain-containing protein 3; Sac domain-containing inositol phosphatase 3; phosphatidylinosit

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.

Pathway

3-phosphoinositide biosynthesis; 3-phosphoinositide biosynthesis; Metabolism; Metabolism; Metabolism of lipids and lipoproteins; Metabolism of lipids and lipoproteins; PI Metabolism; PI Metabolism; Phospholipid metabolism; Phospholipid metabolism; Synthesis of PIPs at the Golgi membrane;