Anti-FIBP monoclonal antibody (DCABH-687)

Mouse anti-Human FIBP monoclonal antibody for sELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Species Reactivity
Human
Immunogen
Recombinant full length protein, corresponding to amino acids 1-358 of Human FIBP with Proprietary tag (tag alone is 26 KDa) (AAH14388).
Conjugate
Unconjugated

Applications


Application Notes
Sandwich ELISA: 10 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
FIBP; fibroblast growth factor (acidic) intracellular binding protein; acidic fibroblast growth factor intracellular-binding protein; FGFIBP; aFGF intracellular-binding protein; FGF-1 intracellular-binding protein
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FIBP (FGF1 Intracellular Binding Protein) is a Protein Coding gene. GO annotations related to this gene include fibroblast growth factor binding. Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.
Antigen Description
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity). Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene. Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. The function about FIBP antigen include fibroblast growth factor binding.

Citations


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References


YAMADA, K; YOSHITAKE, Y; et al. ROLES OF VARIOUS GROWTH-FACTORS IN GROWTH OF HUMAN OSTEOSARCOMA CELLS WHICH CAN GROW IN PROTEIN-FREE MEDIUM. CELL STRUCTURE AND FUNCTION 17:9-17(1992).
SAKAGUCHI, K; et al. ACIDIC FIBROBLAST GROWTH-FACTOR AUTOCRINE SYSTEM AS A MEDIATOR OF CALCIUM-REGULATED PARATHYROID CELL-GROWTH. JOURNAL OF BIOLOGICAL CHEMISTRY 267:24554-24562(1992).

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