Clinicopathological Characteristics of Esophageal Squamous Cell Carcinoma in Patients Younger Than 50 years
ANNALS OF SURGICAL ONCOLOGY
Authors: Kasagi, Yuta; Morita, Masaru; Otsu, Hajime; Kawano, Hiroyuki; Ando, Koji; Hiyoshi, Yukiharu; Ito, Shuhei; Miyamoto, Yuji; Saeki, Hiroshi; Oki, Eiji; Maehara, Yoshihiko
Abstract
This study clarifies age differences in clinicopathologic characteristics and risk factor exposure of patients who have undergone esophagectomy for esophageal cancer (EC). Clinical results of esophagectomy were compared between 22 patients younger than 50 years of age (Group I) and 327 patients older than 50 years of age (Group II) with esophageal squamous cell carcinoma. The two groups did not significantly differ in clinicopathological characteristics, including prognosis. Postoperative pulmonary complication incidence rates were 4.2 % (Group I) and 14.4 % (Group II). In Group I, the incidence of multiple ECs was 36.4 %, and association with head and neck cancer was 31.8 %, which were significantly higher than in Group II (13.4 %, p = 0.021; and 9.2 %, p = 0.015, respectively). Furthermore, the patients in Group I with multiple cancers were almost all heavy smokers and/or users of alcohol. These results suggest that multiple upper aerodigestive tract cancers are associated with heavy exposure to risk factors in patients younger than 50 years of age.
Chromosomal Aberrations in ETV6/RUNX1-positive Childhood Acute Lymphoblastic Leukemia using 244K Oligonucleotide Array Comparative Genomic Hybridization
MOLECULAR CYTOGENETICS
Authors: Zakaria, Zubaidah; Ahid, Mohd Fadly Md; Ismail, Azli; Keoh, Ten Sew; Nor, Nooraisyah Mohamad; Kamaluddin, Nor Rizan; Esa, Ezalia; Yuen, Lam Kah; Rahman, Eni Juraida Abdul; Osman, Raudhawati
Abstract
Background: Acute lymphoblastic leukemia (ALL) is a heterogeneous form of hematological cancer consisting of various subtypes. We are interested to study the genetic aberration in precursor B-cell ALL with specific t(12; 21) translocation in childhood ALL patients. A high resolution 244K array-based Comparative Genomic Hybridization (array-CGH) was used to study eleven ETV6/RUNX1-positive childhood acute lymphoblastic leukemia (ALL) patients. Result: 155 chromosomal aberrations (119 losses, 36 gains) were reported in the array findings, corresponding to 76.8% deletions and 23.2% amplifications. The ETV6 gene deletion occurred in 4 of the patients, corresponding to 45% of the sample. The most common alterations above 1 Mb were deletion 6q (13%), 12p (12%) and 9p (8%), and duplication 4q (6%) and Xq (4%). Other genes important in ALL were also identified in this study including RUNX1, CDKN2A, FHIT, and PAX5. The array-CGH technique was able to detect microdeletion as small as 400 bp. Conclusion: The results demonstrate the usefulness of high resolution array-CGH as a complementary tool in the investigation of ALL.
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