Synthetic peptide corresponding to a region within internal sequence amino acids 243-292 (VVTHSEITKA SRKRLTVSLA YSESHQIRVS QQDFRLFRTL FLLMVSFFIM) of Human GPCR GPR120.
Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects particulary in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediates the taste of fatty acids.
Pathway
Class A/1 (Rhodopsin-like receptors); GPCR ligand binding; Metabolism of proteins; Signal Transduction
Citations
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