Anti-FEV (aa 31-130) polyclonal antibody

Species Reactivity

Human

Immunogen

FEV (NP_059991, 31 a.a. ~ 130 a.a) partial recombinant protein with GST tag. The sequence is PSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGER KSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQG

Conjugate

Alternative Names

FEV; FEV (ETS oncogene family); PET-1; HSRNAFEV; protein FEV; fifth Ewing variant protein; PC12 ETS domain-containing transcription factor 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations.

Pathway

SIDS Susceptibility Pathways; Transcriptional misregulation in cancer;