Anti-FDX1 monoclonal antibody (DCABH-121)

Rabbit anti-Human FDX1 monoclonal antibody for WB, IP, IHC-P, ICC Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS5730
Species Reactivity
Mouse, Rat, Human
Immunogen
A synthetic peptide corresponding to residues in Human Adrenodoxin.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/10000; IP: 1/10 - 1/100; IHC-P: 1/50 - 1/100; ICC: 1/50 - 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
FDX1; ferredoxin 1; FDX; adrenodoxin, mitochondrial; adrenodoxin; ADX
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FDX1 (Ferredoxin 1) is a Protein Coding gene. Diseases associated with FDX1 include cerebrotendinous xanthomatosis and vitamin d-dependent rickets, type i. Among its related pathways are Metabolism and Infectious disease. GO annotations related to this gene include iron ion binding and iron-sulfur cluster binding. An important paralog of this gene is ENSG00000167807. This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21.
Antigen Description
Participates in the synthesis of thyroid hormones. Transfers electrons from adrenodoxin reductase to the cholesterol side chain cleavage cytochrome P450. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Adrenal ferredoxin also known as adrenodoxin or adrenodoxin, mitochondrial or hepatoredoxin or ferredoxin-1 (FDX1) is a protein that in humans is encoded by the FDX1 gene. In addition to the expressed gene at this chromosomal locus (11q22), there are pseudogenes located on chromosomes 20 and 21. Ferredoxin-1 is a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to a terminal cytochrome P450. This particular oxidation/reduction system is found in steroidogenic tissues, and is involved with the synthesis of bile acid and vitamin D. Ferredoxin-1 has been identified in a number of different tissues but all forms have been shown to be identical and are not tissue specific. The function about FDX1 antigen include 2 iron, 2 sulfur cluster binding; NADPH-adrenodoxin reductase activity; cholesterol monooxygenase (side-chain-cleaving) activity; electron carrier activity; enzyme binding; iron ion binding; metal ion binding.

Citations


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References


HOWITT, CA; SMITH, GD; et al. CYANIDE-INSENSITIVE OXYGEN-UPTAKE AND PYRIDINE-NUCLEOTIDE DEHYDROGENASES IN THE CYANOBACTERIUM ANABAENA PCC-7120. BIOCHIMICA ET BIOPHYSICA ACTA 1141:313-320(1993).
Quiles, MJ; Garcia, A; et al. Localization of the chloroplast NAD(P)H dehydrogenase complex in stroma thylakoids from barley. PLANT SCIENCE 146:17-25(1999).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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