May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.
Pathway
Complement cascade; Ficolins bind to repetitive carbohydrate structures on the target cell surface; Initial triggering of complement; Lectin pathway of complement activation.
Citations
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