Anti-FBXW8 (aa 499-598) polyclonal antibody

Species Reactivity

Human

Immunogen

FBXW8 (NP_699179, 499 a.a. ~ 598 a.a) partial recombinant protein with GST tag. The sequence is VWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRA YEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV

Conjugate

Alternative Names

FBXW8; F-box and WD repeat domain containing 8; FBW6; FBW8; FBX29; FBXW6; FBXO29; F-box/WD repeat-containing protein 8; F-box only protein 29; F-box and WD-40 domain protein 8; F-box and WD-40 domain-containing protein 8;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Pathway

Adaptive Immune System; Proteasome degradation; presentation; Ubiquitin mediated proteolysis