Anti-FBXW5 (aa 324-350) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Human FBXW5 aa 324-350 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q969U6

Conjugate

Application Notes

WB: 1/100 - 1/500.

Alternative Names

FBXW5; F-box and WD repeat domain containing 5; F box and WD 40 domain protein 5; F-box/WD repeat-containing protein 5; DKFZP434B205; Fbw5; MGC20962; WD repeat-containing F-box protein FBW5; F-box and WD-40 domain-containing protein 5; DKFZp434B205;

Entrez Gene ID

UniProt ID

Antigen Description

FBXW5 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW5 contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.

Pathway

Association of TriC/CCT with target proteins during biosynthesis; Chaperonin-mediated protein folding; Metabolism of proteins; Protein folding;