Anti-FBXW12 monoclonal antibody (DCABH-11540) Made to order

Rabbit anti-Human FBXW12 monoclonal antibody for WB, ELISA

View other FBXW12 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FBXW12 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FBXW12; F-box and WD repeat domain containing 12; F box and WD 40 domain protein 12 , F box only protein 35 , FBXO35; F-box/WD repeat-containing protein 12; Fbw12; F-box only protein 35
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FBXW12 (F-Box And WD Repeat Domain Containing 12) is a Protein Coding gene. Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al. , 2004 [PubMed 15520277]).
Antigen Description
Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al. , 2004 [PubMed 15520277]). Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Citations


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References


Balamurugan, K; Wang, JM; et al. The tumour suppressor C/EBP delta inhibits FBXW7 expression and promotes mammary tumour metastasis. EMBO JOURNAL 29:4106-4117(2010).
Bai, XD; Adams, BJ; et al. Transcriptomic analysis of the entomopathogenic nematode Heterorhabditis bacteriophora TTO1. BMC GENOMICS 10:-(2009).

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