Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
Have you cited DPABH-26853 in a publication? Let us know and earn a reward for your research.
Tada, H; Okano, HJ; et al. Fbxo45, a Novel Ubiquitin Ligase, Regulates Synaptic Activity. JOURNAL OF BIOLOGICAL CHEMISTRY 285:3840-3849(2010).
Wu, G; He, X; et al. Threonine 41 in beta-catenin serves as a key phosphorylation relay residue in beta-catenin degradation. BIOCHEMISTRY 45:5319-5323(2006).
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COA
Certificate of Analysis
