Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.
Pathway
Adaptive Immune System; Antigen processing: Ubiquitination & Proteasome degradation; Association of TriC/CCT with target proteins during biosynthesis; Chaperonin-mediated protein folding; Class I MHC mediated antigen processing & presentation
Citations
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