Anti-FBXL7 monoclonal antibody (DCABH-11519) Made to order

Rabbit anti-Human FBXL7 monoclonal antibody for WB, ELISA

View other FBXL7 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FBXL7 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FBXL7; F-box and leucine-rich repeat protein 7; F-box/LRR-repeat protein 7; FBL6; FBL7; KIAA0840
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FBXL7 (F-Box And Leucine-Rich Repeat Protein 7) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL16. This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene.
Antigen Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest. F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene. 0The function about FBXL7 antigen include ubiquitin-protein ligase activity.

Citations


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References


Coon, TA; Glasser, JR; et al. Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest. CELL CYCLE 11:721-729(2012).
Wang, XS; Pankratz, VS; et al. Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. HUMAN MOLECULAR GENETICS 19:2886-2897(2010).

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