Anti-FARP1 monoclonal antibody (DCABH-11497) Made to order

Rabbit anti-Human FARP1 monoclonal antibody for WB, ELISA

View other FARP1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FARP1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FARP1; FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); FERM, RhoGEF and pleckstrin domain-containing protein 1; CDEP; MGC87400; PLEKHC2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FARP1 (FERM, ARH/RhoGEF And Pleckstrin Domain Protein 1) is a Protein Coding gene. Among its related pathways are Regulation of RhoA activity. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and Rac GTPase binding. An important paralog of this gene is FRMD3. This gene encodes a protein containing a FERM (4. 2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants.
Antigen Description
This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4. 1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene. 0The function about FARP1 antigen include Rho guanyl-nucleotide exchange factor activity; binding; cytoskeletal protein binding; guanyl-nucleotide exchange factor activity.
Pathway
Regulation of RhoA activity, organism-specific biosystem.

Citations


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References


Cheadle, L; Biederer, T; et al. Activity-Dependent Regulation of Dendritic Complexity by Semaphorin 3A through Farp1. JOURNAL OF NEUROSCIENCE 34:7999-8009(2014).
Stamova, BS; Apperson, M; et al. Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral blood. BMC MEDICAL GENOMICS 2:-(2009).

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