Anti-F2RL2 monoclonal antibody (DCABH-11476) Made to order

Rabbit anti-Human F2RL2 monoclonal antibody for WB, ELISA

View other F2RL2 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human F2RL2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
F2RL2; coagulation factor II (thrombin) receptor-like 2; proteinase-activated receptor 3; PAR3; proteinase activated receptor 3; thrombin receptor-like 2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
F2RL2 (Coagulation Factor II Thrombin Receptor Like 2) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and thrombin receptor activity. An important paralog of this gene is GPR132. This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms.
Antigen Description
Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues. Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene. Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to G proteins. The function about F2RL2 antigen include G-protein coupled receptor activity; phosphatidylinositol phospholipase C activity; protein binding; receptor activity; signal transducer activity; thrombin receptor activity.
Pathway
CDC42 signaling events, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Karoly, ED; Li, ZW; et al. Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure. ENVIRONMENTAL HEALTH PERSPECTIVES 115:535-540(2007).

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