Anti-F1F0-α monoclonal antibody (DMAB7468)

Mouse anti-Bovine F1F0-α monoclonal antibody for ICC, WB, Inhib Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
8I11CE5G10
Species Reactivity
Bovine
Immunogen
bovine Complex V
Conjugate
Unconjugated

Target


Alternative Names
Complex V; F1F0ATPase; ATP synthase; MS501c; ATP synthase alpha

Product Background


Antigen Description
Complex V, also called F1F0ATPase or ATP synthase, is responsible for ATP production in oxidative phosphorylation and can work in reverse as a proton pumping ATPase. The enzyme was thought to be localized exclusively to mitochondria. However, it has recently been identified on the plasma membrane of several cell types including hepatocytes where it functions as the HDL receptor, on endothelial cells where it may act as the angiostatin receptor, and on the surface of cancer cells. The enzyme in mammals is composed of 17 subunits, five of which make up the easily detached F1. The remainder subunits are components of two stalk domains and the proton pumping F0 part of the machinery. Two of the subunits of the F0 part are encoded on mitochondrial DNA while the other subunits are nuclear encoded. Mutations in the mitochondrial-encoded subunits of ATP synthase (Complex V) cause OXPHOS disease.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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