General Notes
This product (Catalog No. DPABH-22537) is a rabbit-derived polyclonal antibody raised against human ETFA, targeting the amino acid region 52–295 of the protein. This antibody exhibits cross-reactivity with Human ETFA from mouse and rat. It has been affinity purified by Protein A. The ETFA gene encodes the alpha subunit of electron transfer flavoprotein (ETF), a heterodimeric enzyme located in the mitochondrial matrix that plays a critical role in transferring electrons from flavin-containing dehydrogenases to the respiratory chain, facilitating the beta-oxidation of fatty acids and the catabolism of certain amino acids for energy production. This subunit, along with the beta subunit encoded by ETFB, forms a flavin adenine dinucleotide (FAD)- and AMP-binding complex that interacts with ETF:ubiquinone oxidoreductase (ETFDH) to link multiple dehydrogenases to the electron transport chain. Defects in ETFA disrupt this electron shuttling process, leading to metabolic disorders characterized by the accumulation of acyl-CoA intermediates and toxic byproducts.
DPABH-22537 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-22537 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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