ESPL1 (NP_036423, 586 a.a. ~ 701 a.a) partial recombinant protein with GST tag. The sequence is REELQAYKAVRADTGQERFNIICDLLELSPEETPAGAWARATHLVELAQVLCYHDFTQQT NCSALDAIREALQLLDSVRPEAQARDQLLDDKAQALLWLYICTLEAKIQEGIERDR
Conjugate
Unconjugated
Target
Alternative Names
ESPL1; extra spindle pole bodies homolog 1 (S. cerevisiae); ESP1; SEPA; separin; caspase-like protein ESPL1; extra spindle poles like 1; separin, cysteine protease; extra spindle poles-like 1 protein;
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]
Pathway
Cell Cycle; Cell cycle; M Phase; Mitotic Metaphase and Anaphase.
Citations
Publication ()
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