Anti-ERRFI1 (aa 221-449) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment, corresponding to a region within amino acids 221 and 449 of Human ERRFI1 (Uniprot ID Q9UJM3)

Conjugate

Application Notes

WB: 1/500 - 1/3000.

Alternative Names

ERRFI1; ERBB receptor feedback inhibitor 1; GENE 33; MIG 6; RALT; mitogen-inducible gene 6 protein; receptor-associated late transducer; MIG6; MIG-6; GENE-33;

Entrez Gene ID

UniProt ID

Antigen Description

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.

Pathway

EGFR1 Signaling Pathway;