Mouse anti-Human ERCC6 polyclonal antibody

Species Reactivity

Human

Immunogen

ERCC6 (NP_000115, 1394 a.a. ~ 1493 a.a) partial recombinant protein with GST tag. The sequence is RARNHLILPERLESESGHLQEASALLPTTEHDDLLVEMRNFIAFQAHTDGQASTREILQE FESKLSASQSCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

Conjugate

Alternative Names

ERCC6; excision repair cross-complementation group 6; CSB; CKN2; COFS; ARMD5; COFS1; RAD26; UVSS1; DNA excision repair protein ERCC-6; ATP-dependent helicase ERCC6; cockayne syndrome protein CSB; Cockayne syndrome group B protein; excision repair cross-co

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Naturally-occurring readthrough transcription occurs between this gene and the adjacent PGBD3 gene (GeneID:267004), and results in a fusion protein that shares sequence with the product of each individual gene. The readthrough locus is represented by GeneID:101243544.

Pathway

DNA Repair; Formation of transcription-coupled NER (TC-NER) repair complex; Nucleotide Excision Repair; Nucleotide excision repair