Recombinant full length protein corresponding to Human XPG aa 1-1186. NCBI: NP_000114.2Sequence: MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSI ENPHLLTLFHRLCKLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASS DSRKTTEKLLKTFLKRQAIKTAFRSKRDEALPSLTQVRRENDLYVLPPLQ EEEKH
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/1000;
Target
Alternative Names
ERCC5; excision repair cross-complementation group 5; XPG; UVDR; XPGC; COFS3; ERCM2; DNA repair protein complementing XP-G cells; XPG-complementing protein; DNA excision repair protein ERCC-5; xeroderma pigmentosum, complementation group G; excision repai
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.
Pathway
DNA Repair; Dual incision reaction in TC-NER; Formation of transcription-coupled NER (TC-NER) repair complex; Nucleotide Excision Repair.
Citations
Publication ()
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