Anti-ERAP1 monoclonal antibody, clone FQS7170

Antibody Isotype

IgG

Clone

FQS7170

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to C-terminal amino acids of Human ARTS1.

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100; ICC: 1/250 - 1/500;

Alternative Names

ERAP1; endoplasmic reticulum aminopeptidase 1; A LAP; adipocyte derived leucine aminopeptidase; aminopeptidase regulator of TNFR1 shedding; ARTS 1; ERAAP1; KIAA0525; PILS AP; puromycin insensitive leucyl specific aminopeptidase; aminopeptidase PILS; adipo

Entrez Gene ID

UniProt ID

Antigen Description

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Pathway

Adaptive Immune System, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem;