Anti-EPM2A (aa 131-144) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide: C-EATGHTNEMKHTTD, corresponding to internal sequence amino acids 131-144 of Human EPM2A (NP_005661.1).

Conjugate

Application Notes

IHC-P: 2.5 - 3.75 μg/ml; WB: 0.1 - 0.3 μg/ml.

Alternative Names

EPM2A; epilepsy, progressive myoclonus type 2A, Lafora disease (laforin); epilepsy, progressive myoclonus type 2, Lafora disease (laforin); laforin; LD; LDE; LAFPTPase; lafora PTPase; EPM2; MELF;

Entrez Gene ID

UniProt ID

Antigen Description

Dual specificity protein phosphatase. May be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Forms a complex with NHLRC1/malin and HSP70 and this complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Isoform 2, an inactive phosphatase, could function as a dominant-negative regulator for the phosphatase activity of isoform 1.