Magic™ Anti-EPH A3+A4+A5 (Phospho Y779, 779, 833) monoclonal antibody, clone FQS6795

Antibody Isotype

IgG

Clone

FQS6795

Species Reactivity

Mouse; Rat; Human

Immunogen

Phospho specific peptide corresponding to residues surrounding Tyrosine 779, Tyrosine 779, and Tyrosine 833 of EPH A3+A4+A5 respectively (P29320, P54756, P54764).

Conjugate

Application Notes

WB: 1/1000 - 1/10000.

Alternative Names

EPHA3; EPH receptor A3; EphA3 , ETK, ETK1, TYRO4; ephrin type-A receptor 3; HEK; HEK4; EPH-like kinase 4; human embryo kinase 1; eph-like tyrosine kinase 1; TYRO4 protein tyrosine kinase; tyrosine-protein kinase receptor ETK1; EK4; ETK; ETK1; TYRO4;

Entrez Gene ID

UniProt ID

Antigen Description

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal andhippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.

Pathway

Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; EPHA forward signaling, organism-specific biosystem; EphrinA-EPHA pathway, organism-specific biosystem;