Anti-ENOX1 monoclonal antibody (DCABH-11411) Made to order

Rabbit anti-Human ENOX1 monoclonal antibody for WB, ELISA

View other ENOX1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ENOX1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ENOX1; ecto-NOX disulfide-thiol exchanger 1; cCNOX; CNOX; FLJ10094; PIG38
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ENOX1 (Ecto-NOX Disulfide-Thiol Exchanger 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and oxidoreductase activity. An important paralog of this gene is ENOX2. Electron transport pathways are generally associated with mitochondrial membranes, but non-mitochondrial pathways are also biologically significant. Plasma membrane electron transport pathways are involved in functions as diverse as cellular defense, intracellular redox homeostasis, and control of cell growth and survival. Members of the ecto-NOX family, such as CNOX, or ENOX1, are involved in plasma membrane transport pathways. These enzymes exhibit both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity in series, with each activity cycling every 22 to 26 minutes (Scarlett et al. , 2005 [PubMed 15882838]).
Antigen Description
Electron transport pathways are generally associated with mitochondrial membranes, but non-mitochondrial pathways are also biologically significant. Plasma membrane electron transport pathways are involved in functions as diverse as cellular defense, intracellular redox homeostasis, and control of cell growth and survival. Members of the ecto-NOX family, such as CNOX, or ENOX1, are involved in plasma membrane transport pathways. These enzymes exhibit both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity in series, with each activity cycling every 22 to 26 minutes (Scarlett et al. , 2005 [PubMed 15882838]). Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock. The function about ENOX1 antigen include nucleic acid binding; nucleotide binding; oxidoreductase activity.

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References


Morre, DJ; Hostetler, B; et al. Cancer type-specific tNOX isoforms: A putative family of redox protein splice variants with cancer diagnostic and prognostic potential. BIOFACTORS 34:201-207(2008).
Herraez, DL; Martinez-Bueno, M; et al. Rheumatoid Arthritis in Latin Americans Enriched for Amerindian Ancestry is Associated With Loci in Chromosomes 1, 12, and 13, and the HLA Class II Region. ARTHRITIS AND RHEUMATISM 65:1457-1467(2013).

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