Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]
Pathway
Activation of gene expression by SREBF (SREBP); Biosynthesis of unsaturated fatty acids; Fatty Acyl-CoA Biosynthesis; Fatty acid biosynthesis; Fatty acid elongation; Fatty acid metabolism; Fatty acid; Metabolism.
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