Anti-ELN monoclonal antibody, clone 21C9

The main objective of this paper is to answer the following question: What are the conditions and possibilities of territorial peace in Colombia? Given that the territorial dimension of peace constitutes one of the most important cornerstones of the Colombian government's peace agreement with the FARC and negotiations with the ELN, this paper attempts to describe the realities and challenges of local peace processes in Colombia. To achieve these aims, the dynamics of direct violence and structural violence in six regions of the country were analyzed. Quantitative data were drawn from 246 surveys of Colombian men and women mayors conducted from 2014 to 2015. To address direct violence, figures provided by the Observatory on Human Rights and International Humanitarian Law of the Office of the President and the United Nations Office on Drugs and Crime were used. Structural violence was analyzed based on official figures of the Department of Social Prosperity and the National Department of Statistics. The most relevant finding is that several regions of Colombia, especially in the south and in the east, the problem of direct and structural violence is particularly pressing. This situation is very likely to be one of the main challenges to consolidating the peace process negotiated recently with the FARC and which, quite possibly, will also take place with the ELN in the medium term.

Aim: The cytogenetic and molecular features of leukemia cells are chief predictors of survival in acute myeloid leukemia (AML). However, treatment outcomes in AML differ between low-, medium and high-income countries. We thus aimed to investigate the relevance of the European Leukemia Net (ELN) prognostic system in Romanian AML patients. Material and methods: We investigated the clinical significance of the ELN recommendations in 130 newly diagnosed AML patients treated at the Iasi Regional Oncology Institute. Results: Favorable, intermediate and adverse risk ELN classes had a similar distribution and retained their prognostic relevance (median overall survival of 18, 11 and 2 months respectively at a median follow-up duration of 18 months) when compared with literature data. However, in both the chemotherapy eligible and ineligible patients a higher prevalence of comorbid conditions and treatment related mortality could be identified. Conclusions: The management of Romanian AML patients poses significant challenges mainly due to higher incidence of comorbid conditions and infections. However, growing access to the allogeneic stem cell transplant procedure in our country will significantly improve the outcome of these patients.