Anti-ELMO3 monoclonal antibody (DCABH-11399) Made to order

Rabbit anti-Human ELMO3 monoclonal antibody for WB, ELISA

View other ELMO3 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ELMO3 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ELMO3; engulfment and cell motility 3; engulfment and cell motility 3 (ced 12 homolog, C. elegans); engulfment and cell motility protein 3; CED 12; CED12
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ELMO3 (Engulfment And Cell Motility 3) is a Protein Coding gene. Among its related pathways are Shigellosis and Bacterial invasion of epithelial cells. GO annotations related to this gene include binding and SH3 domain binding. An important paralog of this gene is ELMO1. The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes.
Antigen Description
The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). The function about ELMO3 antigen include SH3 domain binding; binding.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Coskun, M; Boyd, M; et al. Control of Intestinal Promoter Activity of the Cellular Migratory Regulator Gene ELMO3 by CDX2 and SP1. JOURNAL OF CELLULAR BIOCHEMISTRY 109:1118-1128(2010).
Kristensen, LS; Soes, S; et al. ELMO3: A direct driver of cancer metastasis?. CELL CYCLE 13:2483-2484(2014).

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