Anti-eIF3G (aa 216-265) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: PSLRDGASRR GESMQPNRRA DDNATIRVTN LSEDTRETDL QELFRPFGSI , corresponding to a region within internal sequence amino acids 216 - 265 of Human EIF3S4 (NP_003746)

Conjugate

Application Notes

Peptide ELISA: 1/62500; ICC/IF: 1/500; IP: 1/500; WB: 1 μg/ml;

Alternative Names

EIF3G; eukaryotic translation initiation factor 3, subunit G; EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta; eukaryotic translation initiation factor 3 subunit G; eIF3 p42; eIF3 p44; eIF-3-delta; eIF-3 RNA-binding subunit; eukaryotic translation initiation facto

Entrez Gene ID

UniProt ID

Antigen Description

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA.

Pathway

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S; Eukaryotic Translation Initiation; Formation of the ternary complex, and subsequently, the 43S complex; Gene Expression