Anti-eIF3C (C-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide between residues 850 and 913 C terminal (Human).

Conjugate

Application Notes

WB: 1/15000 - 1/30000; IP: 2-10 μg/mg;

Alternative Names

EIF3C; eukaryotic translation initiation factor 3, subunit C; EIF3CL; EIF3S8; eIF3-p110; eukaryotic translation initiation factor 3 subunit C; eIF3 p110; cell migration-inducing protein 17; eukaryotic translation initiation factor 3 subunit 8; eukaryotic

Entrez Gene ID

UniProt ID

Antigen Description

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Pathway

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S; Eukaryotic Translation Initiation; Formation of the ternary complex, and subsequently, the 43S complex; Gene Expression