Anti-eIF2C3 monoclonal antibody (DCABH-11380) Made to order

Rabbit anti-Human eIF2C3 monoclonal antibody for WB, ELISA

View other eIF2C3 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human EIF2C3 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
EIF2C3; eukaryotic translation initiation factor 2C, 3; protein argonaute-3; AGO3; argonaute 3; FLJ12765
Entrez Gene ID
UniProt ID

Product Background


Gene summary
AGO3 (Argonaute 3, RISC Catalytic Component) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PIWIL4. This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
Antigen Description
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. The function about eIF2C3 antigen include RNA binding; protein binding; translation initiation factor activity.
Pathway
Gene Expression, organism-specific biosystem; MicroRNA (miRNA) Biogenesis, organism-specific biosystem; Post-transcriptional Silencing By Small RNAs, organism-specific biosystem; Pre-NOTCH Expression and Processing, organism-specific biosystem; Pre-NOTCH Transcription and Translation, organism-specific biosystem; Regulatory RNA pathways, organism-specific biosystem; Signal Transduction, organism-specific biosystem.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Li, L; Yu, CH; et al. Argonaute proteins: potential biomarkers for human colon cancer. BMC CANCER 10:-(2010).

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