Mouse anti-Human EIF2AK4 polyclonal antibody

Species Reactivity

Human

Immunogen

EIF2AK4 (NP_001013725, 1401 a.a. ~ 1500 a.a) partial recombinant protein with GST tag. The sequence is VVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGS HVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG

Conjugate

Alternative Names

EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4; GCN2; PVOD2; eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein; GCN2 eIF2alpha kinase; general control nonderepressible 2;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.

Pathway

Epstein-Barr virus infection; Herpes simplex infection; Measles;