Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation. Isoform p40 and isoform p43 exhibit the same level of activity.
Pathway
Cellular response to hypoxia; HIF-1 signaling pathway; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Regulation of Hypoxia-inducible Factor (HIF) by oxygen
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