EGLN1 (NP_071334, 272 a.a. ~ 355 a.a) partial recombinant protein with GST tag. The sequence is LMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLN KDWDAKVSGGILRIFPEGKAQFAD
Conjugate
Unconjugated
Target
Alternative Names
EGLN1; egl-9 family hypoxia-inducible factor 1; HPH2; PHD2; SM20; ECYT3; HPH-2; HIFPH2; ZMYND6; C1orf12; HIF-PH2; egl nine homolog 1; egl nine-like protein 1; HIF prolyl hydroxylase 2; HIF-prolyl hydroxylase 2; zinc finger MYND domain-containing protein 6
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
Pathway
Cellular response to hypoxia; HIF-1 signaling pathway; HIF-2-alpha transcription factor network; Pathways in cancer
Citations
Publication ()
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