General Notes
This product (Catalog No. DPABH-09135) is a rabbit-derived polyclonal antibody raised against human EGF, targeting the amino acid region 608–751 of the protein. It has been affinity purified by Protein A. EGF (pro-epidermal growth factor, pro-EGF) encodes a membrane-anchored precursor protein that is proteolytically processed to generate mature epidermal growth factor (EGF), a potent mitogenic peptide. Pro-EGF contains an extracellular EGF domain that can be cleaved by specific proteases to release soluble EGF, which then binds to the EGFR and activates downstream signaling pathways such as RAS/MAPK and PI3K/AKT, promoting cell proliferation, differentiation, and survival. Pro-EGF is expressed in multiple epithelial and glandular tissues and plays an important role in tissue development, repair, and homeostasis. Dysregulation of EGF signaling has been associated with tumorigenesis, fibrosis, and abnormal wound healing.
DPABH-09135 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-09135 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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